Probiotics and The
A Case for Protective Nutrients
The “hygiene hypothesis” helps to explain the fact that immune disorders
are increasing while improved
hygiene and antibiotics have
caused infectious diseases to decrease
during the last half century.
With the evidence mounting that immune disorders are increasing – especially in North America
and Europe – this webcast explores how decreased microbial exposure – even from vaccinations
and improved sanitation – can lead to abnormal responses to allergens and autoantigens in the
mucosal immune system.
It also offers encouraging scientific evidence that probiotic administration may prevent and reduce
the immune-mediated disease trend. Probiotics are living organisms, which when administered in
adequate amounts, confer a health benefit on the host.
Regular consumption of certain probiotics can help regulate the balance of bacteria in the digestive
tract and reinforce mucosal defenses that helps limit the propagation of immune mediated disease
bacteria. Probiotics have been used historically by many societies worldwide to promote health.
Below are links to each of the presentations given at the live
Symposium held at the 2006 Experimental Biology Annual Conference in San Francisco, CA on April 3, 2006. Each
of the links will open the presentation in a new window. System
Requirements: You will need Macromedia's Flash player to view these presentations.
Welcome and Introduction
W. Allan Walker, MD
Director, Division of Nutrition,
Harvard Medical School
Director of Mucosal Immunology Laboratory,
Massachusetts General Hospital
Conrad Taff Professor of Nutrition, Harvard Medical
The Effect of Infections on Susceptibility to Allergic and Autoimmune Diseases
Nathalie Thieblemont, PhD
CNRS, Hôpital Necker, Paris, France
Discussion of the Bach NEJM article in 2002 and recent work on the role of pathogen TLR antagonists in protection against autoimmune disease
Counter-Regulation and the Hygiene Hypothesis
Christopher Karp, MD
Esiason Professor of Pediatrics, Children’s Hospital,
University of Cincinnati, Ohio
Update of thesis of regulatory T-cells in the hygiene hypothesis published in Nature Immunology, 2000.
Postnatal maturation of immune function and risk for atopic disease
Patrick Holt, DSc, FRCpath, FAA
Head, Division of Cell Biology
Telethon Institute for Child Health Research,
West Perth, Australia
Recent clinical data on TH1/
TH2 imbalance and development of allergy
Mechanism(s) of the probiotic affect in atopic disease
W. Allan Walker, MD
Review mechanisms from a basic perspective of
work that has been done in the Massachusetts
General Hospital laboratory, as well as clinical work.
Probiotics and Intestinal Health in Children
Click here to download the Proceedings from the October 9, 2005 Symposium, "Probiotics and Intestinal Health in Children," held at the
2005 American Academy of Pediatrics Annual National Conference in Washington, DC. (PDF format)
Note: You will need the free Adobe Acrobat Reader to view this document. You can download a free version here if you do not already have the free viewer.
Program made possible by an unrestricted
educational grant provided by
The Dannon Company, Inc. and Yakult Honsha Co., Ltd.